The FDA has sent a complete response letter to AstraZeneca asking for additional information on its application for approval of quetiapine fumarate in major depressive disorder, the company announced. The drug is already approved for bipolar disorder and schizophrenia.
Medscape Medical News
A new study suggests that between 1998 and 1999, Medicare managed-care plans had no positive effect on the appropriate use of carotid endarterectomy, referral to high-volume providers, or outcomes, failing to deliver on their promise, researchers say.
Medscape Medical News
Cerebellar development, risk factors for injury, and long-term developmental consequences of injury are discussed. What are the implications for nursing practice, education, and research?
Neonatal Network: The Journal of Neonatal Nursing
Review the effects of selective histamine antagonism and potential clinical applications for insomnia management.
Although statins have been shown to have beneficial clinical effects in hypertensive patients, researchers state the "favorable effects are via mechanisms that are independent of important effects on large-artery function and central pressure."
Heartwire
This is a rare case of restless legs syndrome (RLS) associated with hyperparathyroidism. To our knowledge, it is the second such case of hyperparathyroid-related RLS that has been described.
The Medscape Journal of Medicine
Normal age-related memory decline appears partly explained by increased blood glucose levels that cause decreased activity in the dentate gyrus, a new study suggests.
Medscape Medical News
A new analysis from SPORT at 4-year follow-up shows that spine surgery provides more rapid and greater relief of symptoms and improvement in function than nonsurgical options for lumbar disk herniation.
Medscape Medical News
Phenytoin distribution and elimination in the critically ill is hard to predict. What must clinicians know to correctly interpret total phenytoin serum levels especially if protein binding is altered?
Pharmacotherapy
This Best Evidence Review weighs in on a study from the International Journal of Clinical Practice on treatments for opioid-associated bowel dysfunction.
Medscape Family Medicine